COPIC ink is an alcohol-based, fast-drying, permanent and non-toxic ink that works well with watercolours and coloured pencils. This 12 ml refill works for Copic Sketch, Copic Original or Copic Ciao markers and will refill the marker approximately 5 to 8 times, depending on the type of marker. To refill the marker, dab the ink directly onto the broad nib using the attached nozzle or use your Copic Nib Tweezers to remove the nib for even easier refills.